The Company
We are Alloy Therapeutics—a biotechnology ecosystem company empowering the global scientific community to make better medicines together. Through a community of partners, we democratize access to pre-competitive tools, technologies, services, and company creation capabilities that are foundational for discovering and developing therapeutic biologics. The company facilitates affordable, non-exclusive access to the entire drug discovery community from academic scientists, small and medium biotech, to the largest biopharma. At Alloy, we believe our industry should compete on getting the best drugs to patients as quickly as possible, not exclusive access to the best platforms. As a reflection of our relentless commitment to the scientific community, we reinvest 100% of its revenue in innovation and access to innovation. MAY THE BEST DRUG WIN.

Alloy is headquartered in Waltham, MA with additional labs in Cambridge, UK; Basel, CH; San Francisco, CA; and Athens, GA. Successful members thrive in our shared culture of accountability, deliberate trust, and open communication. As a team we aspire to work together to exceed expectations and collectively contribute across the global organization to always maintain our nimble, startup culture. Come thrive at Alloy!

The Program

Alloy’s Predoctoral Fellowship is a paid training program designed to enable the next generation of biotechnology leaders to gain two years of industry experience before transitioning into a top-tier PhD program. The Fellowship is a unique, 24 month experience where you will develop your knowledge and lab skills as you apply for and prepare to start your PhD training in a top-tier graduate program. While you work in the lab, Alloy supports your application process and connects you with our extensive network of collaborators and academic labs. In addition, we offer Predoc Fellows $50,000 in tuition and living reimbursement if they return to Alloy after completion of their PhD program.

Our Predoc Fellows will have the unique opportunity to be immersed in Alloy’s collaborative biotechnology ecosystem and will work side by side with a passionate team of scientists and engineers across our 5 research sites in 3 different countries. Each Predoc will work on developing cutting edge platform technology in one our 6 modalities (Antibodies/Bispecific Antibodies, TCR/TCRm, Genetic Medicines, Cell Therapy, Peptides, and Drug Delivery). Additionally, each Predoc will work to discover new medicines using Alloy’s proprietary technologies in collaboration with our external partners and Venture Studio companies. The Predoc Fellows will play a hands-on role in contributing to our mission to make better medicine, together.

The Team

The Keyway TCR Discovery team uses a proprietary platform to deliver fully integrated discovery service for soluble therapeutics against peptide-MHCs.

The Role

As a Predoctoral Research Fellow, you will work with antibody and TCR discovery teams to design and optimize multiple therapeutic modalities including multi-specifics. You will be developing novel protein engineering solutions utilizing multiple bio-display systems while leveraging expertise from our Structure Biology, Bio-analytics, Bioinformatics and Translational teams at Alloy/Keyway. This is a multi-disciplinary role that requires in-depth knowledge of dry and wet lab protein engineering techniques. This role will report to the Senior Director of TCR Discovery and Protein Engineering in Alloy/Keyway while working and interfacing with various functional groups in a dynamic and fast-paced start-up environment.

How You’ll Drive Impact

• Develop: Design, express, purify and characterize (ELISA or SPR) proteins as part of a technology development project
• Optimize: Enhance function and drug-like properties of antibody fragments, TCRs, multi-specifics and protein fusions
• Deliver: Document data in lab notebook and ensure periodic peer review; present data for review, group discussions, and team meetings

Why We Value You

• You hold an undergraduate degree in Biochemistry, biophysics, chemical biology, structural biology, bioengineering, or a related discipline working extensively with proteins
• You have deep knowledge in integrating biologics deep sequencing into protein engineering strategies
• You have knowledge in Structure-based protein engineering

Desired Multipliers

• Excellent communication, collaboration, and interpersonal skills.
• Self-directed, can work both independently and collaboratively
• Has strong analytical, organizational skills and detail-oriented
• Core competencies include biochemistry & protein engineering and biochemical and/or cell-based assays.
• A strong background in protein biochemistry and protein engineering and lab-based skills
• You have experience screening engineered proteins using display technologies to generate optimal therapeutic biologics

Taking Care of Our People
We support the individuality of what people need to do outside of work to empower them to do their best at work. While you focus on making better medicine together, we focus on programs and benefits that support a diverse and growing team. Whether you’re single, in a growing family, or nearing retirement, Alloy offers a variety of comprehensive and competitive benefits starting from day one.
Compensation

• Competitive base and equity compensation
• 401(k) company match and financial planning
• Unlimited PTO (paid time off) and flexible schedules

Health & Family

• Generous personal and family medical, dental and vision benefits with 90% of premiums and deductibles covered
• Company-paid disability (STD, LTD) and life insurance
• Paid parental leave
• Family planning support up to $50,000 (e.g. IVF/PGT, adoption, surrogacy, egg retrieval)

Unique Perks

• Flexible work schedule built around our team-driven philosophy
• Annual stipend for continuing education with commitment to your career through individualized professional development plan
• Extensive Employee Assistance Program (EAP) including resources for mental wellness
• International travel insurance

Diversity, Equity, and Inclusion
Here at Alloy, we democratize capabilities for discovering and developing therapeutic biologics. So, being diverse and inclusive isn’t just something we strive for, it is who we are, and part of what we do each and every single day. We want to ensure that as an employee, you feel Alloy is a place where, no matter who you are, you feel safe, included, and that you have the opportunity to bring your unique self to work.

Alloy Therapeutics is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, national origin, sex, sexual orientation, gender identity, veteran status, disability, or other legally protected status. If you are unable to submit an application because of incompatible assistive technology or a disability, please contact us at recruiting@alloytx.com. We will make every effort to respond to your request for disability assistance as soon as possible.

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