WHY WORK FOR ARCTURUS?

Founded in 2013 and based in San Diego, California, Arcturus Therapeutics Holdings Inc. (Nasdaq: ARCT) is a global, late-stage clinical mRNA medicines and vaccines company with enabling technologies: (i) LUNAR® lipid-mediated delivery, (ii) STARR™ mRNA Technology (samRNA) and (iii) mRNA drug substance along with drug product manufacturing expertise. Arcturus’ diverse pipeline of RNA therapeutic and vaccine candidates includes mRNA vaccine programs for SARS-CoV-2 (COVID-19) and Influenza, and other programs to potentially treat ornithine transcarbamylase (OTC) deficiency, and cystic fibrosis, along with partnered programs including glycogen storage disease type III, and hepatitis B virus. Arcturus’ versatile RNA therapeutics platforms can be applied toward multiple types of nucleic acid medicines including messenger RNA, small interfering RNA, replicon RNA, antisense RNA, microRNA, DNA, and gene editing therapeutics. Arcturus’ technologies are covered by its extensive patent portfolio (patents and patent applications issued in the U.S., Europe, Japan, China and other countries). Arcturus’ commitment to the development of novel RNA therapeutics has led to collaborations including, amongst others, Janssen Pharmaceuticals, Inc., part of the Janssen Pharmaceutical Companies of Johnson & Johnson, Ultragenyx Pharmaceutical, Inc., and the Cystic Fibrosis Foundation.

Arcturus Therapeutics is presently recruiting outstanding candidates with experience in the field of mRNA technologies and nanoparticle sciences. Our corporate culture is dynamic, diverse, and creative. We value collaboration and teamwork. We seek individuals to join us with a genuine passion for the science behind helping to cure disease and improve the lives of patients.

THE OPPORTUNITY

We are seeking a highly motivated individual who has the desire to excel in a fast-paced biotech environment, to join us as Sr. Research Associate or Engineer I, Drug Substance MSAT reporting to the Director, MSAT and Tech Transfer. In this role, you will work with a team of highly motivated scientists, engineers, as well as external customers and vendors to develop and transfer robust, optimized drug substance and plasmid production processes for CMC programs. You will work with a high degree of independence and will be responsible to provide critical support between R&D and Manufacturing teams, working with both teams to ensure process changes meet program, safety, quality, and regulatory requirements. As CMC programs move through their lifecycle, you will be responsible for managing the execution of process characterization studies, risk assessments, and authoring critical documents in support of regulatory filings. In addition, you will be responsible for providing technical support to the manufacturing process, including conducting risk assessments and execution of focused experiments to aid in deviation and CAPA resolution. We would love the ideal candidate to have experience in nucleic acid, vaccines or gene/cell therapy products, process development.

WHAT YOU WILL CONTRIBUTE

• Works with relevant Development, Manufacturing, QA, and Regulatory teams to gather requirements, execute experiments, and revise document compliant with change management standards.
• Support process development for clinical RNA and pDNA manufacture and participate in smooth technology transfer by writing technology transfer documents and batch records for CGMP manufacturing at CMOs for clinical and commercial campaigns.
• Performs analysis of experimental data and interprets immediate experimental outcomes and/or conclusions within established protocols.
• Captures and documents all relevant information for manufacturing unit operations contributes to the knowledge base for the organization and provides corresponding documentation and reports.
• Exercises good judgment to prioritize studies, considering feasibility and Project impact.
• “Troubleshoots” routine/complex technical problems and performs routine equipment maintenance.
• Validate scale down models and support manufacturing process validation.
• Assist in authoring and reviewing of regulatory submissions.
• Demonstrates effective, self-sufficient communication skills, especially in peer-directed presentations.
• Performs other duties as assigned.
• Develop, execute, and analyze biochemical assays needed for drug substance quality control when needed.

WHAT WE SEEK

• BS degree (or higher) biochemistry, biological sciences, pharmaceutical sciences, chemical engineering, or other relevant disciplines.
• Minimum BS plus 5 years experience, MS plus 3 years experience, or PhD plus 2 years experience.
• Previous GMP process engineering, process development, or manufacturing experience is highly desired.
• Experience in conducting FMEA risk analysis and design, execution, and authoring of internal reports summarizing the results is desired.
• Capable working with cross-functional teams, including QA, QC, and external collaborators.
• Experience with production and production scale-up of RNA, plasmid DNA, and/or proteins desired
• Experience with traditional and modern molecular biology techniques, such as biochemical assays, PCR, Western, and ELISA preferred.
• Must be detail-oriented with demonstrated ability in problem solving and organization.
• Excellent written and oral communication skills.

WHAT WE OFFER

At Arcturus Therapeutics, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family, and wellbeing journey while providing flexibility and resources to support their growth and aspirations. Our total rewards package includes:

• Full range of health benefits including Medical, Dental & Vision with 100% EMPLOYER PAID premiums for employee and family!
• 401k Match
• Employee Stock Purchase Program (ESPP)
• Competitive salaries and bonus plans plus equity via Stock Options
• Catered lunches
• Free variety of snacks and beverages
• Health and Wellness programs
• $100 Anniversary cash awards with opportunity to increase to $2000!
• Referral Bonuses
• On Campus Gym
• Company sponsored FUN events
• Education reimbursement

The anticipated salary range for candidates who will work in San Diego is Salary range: $105,000- $116,000

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience within the job, type and length of experience within the industry, education, etc. Arcturus Therapeutics is multi state employer and this salary range may not reflect positions that work in other states. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements.

For a deeper dive into our company and corporate culture visit www.ArcturusRx.com

Arcturus is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law.